The 35 mile moderate difficulty trail begins at the southern entrance to Sam A. Baker State Park and runs alongside the St. Francis River south for 15 miles through woodlands and field bottoms until it reaches Lake Wappapello at Old Greenville National Historical Site. It then heads south another 15 miles through rolling oak and pine forest hill country and ends at the Black River some eight miles north of Poplar Bluff. Water is available at creeks along most of the trail.